Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium

Purpose: Randomised study to evaluate the role of Cyclosporine eye drops (0.05%) pre & postoperatively on recurrence in cases of recurrent & vascularized pterygium, undergoing excision and Conjunctival Limbal Autograft with Fibrin glue. Materials and Methods: In this prospective study 100 eyes of 100 patients were taken up for study in two groups – Group A (50 eyes) and Group B (50 eyes). Only those eyes that had recurrent or vascularised pterygium were included in the study. Each case in both the groups underwent conjunctival limbal autograft with fibrin glue, after excision of pterygium. Group A received topical Cyclosporine eye drops (0.05%) pre & postoperatively 12 hourly for 04 weeks each, and in addition they also received topical steroids postoperatively for four weeks in tapering doses. Group B received standard of care treatment NSAIDs pre & postoperatively for 04 weeks each and topical steroids in tapering doses for four weeks postoperatively. Any encroachment of conjunctiva more than 1mm inside the limbus was considered as recurrence. Postoperatively patients were followed for recurrence, adverse effect and complications for 06 months in the two groups. Results: Recurrence was seen in 03(6%) of eyes in Group A and 04(8%) of eyes in Group B. Conclusion: Both pre & postoperative use of topical Cyclosporine (0.05%) can be efficacious in further reducing the chances of recurrence after pterygium surgery, although the difference observed was not statistically significant (RR-0.75, P Value-0.69).